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Sitamet 10pcs
50mg + 500mg Tablet. Generic Name: Sitagliptin + Metformin
Each tablet contains two oral antihyperglycemic drugs: Metformin Hydrochloride BP 500mg & Sitagliptin 50 mg as Sitagliptin Phosphate Monohydrate.
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✅ Description:
Sitamet combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride, a member of the biguanide class. Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Concentrations of the active intact hormones are increased by sitagliptin, thereby increasing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are di erent from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease.
Indications: 1. As mono-therapy, as an adjunct to diet to lower blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily managed on diet alone. 2. As adjunct therapy for IDDM in combination with insulin.
Dosage & Administration: Dosage must be individualized on the basis of both e ectiveness and tolerance, while not exceeding the maximum recommended daily dose of 2,550 mg (Metformin). Initially 500 mg (Metformin) twice daily or 850 mg (Metformin) daily with meals increasing gradually if necessary to maximum 3 gm daily. Reduce to maintenance, usually 500 mg (Metformin) thrice or 850 mg (Metformin) twice daily.
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